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Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Therefore, salinomycin may be considered as a promising novel anti-cancer agent despite its largely unknown mechanism of action. Surprisingly, a small scale of clinical trial has demonstrated that salinomycin only exerted minimal side effects at antineoplastic dosages (200–250 μg·kg − 1, i.v., every second day for 3 weeks) in human . Analogously, our data also showed that the cytotoxicity of salinomycin on the UM cells is about 11~21-fold as high as that of the normal retinal pigmented epithelium cells, which implied the safety of salinomycin used in treatment of UM. Five experiments were conducted to test the anticoccidial efficacy of salinomycin (AHR-3096C, A. H. Robins) at 66 ppm and its compatibility with roxarsone (50 ppm) under floor pen conditions Monensin (100, 121 ppm), lasalocid (75, 125 ppm), and shuttle programs of salinomycin-monensin (66/100 ppm) or monensin-salinomycin (100/66 ppm) were included for comparison. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods: Primary tumor-initiating cells (TIC) isolated from human patients with colorectal liver metastases or from human primary colon carcinoma were exposed to salinomycin and compared to treatment with 5-FU and oxaliplatin. Salinomycin is as an antimicrobial and anticoccidial antibiotic.

Salinomycin clinical trial

the clinical trial. This document provides guidance on these aspects. 4. EU Member States, contracting States of the European Economic Area (EEA) (2) and persons who request auth orisation of a clinical trial (applicants), notify substantial amendments, and declare the end of a clinical trial in the Although Sal exhibits predominant anticancer effects in vivo and in vitro experiments and a small number of clinical trials, the exact mechanisms are still unknown. We summarize the autophagy-related researches, providing a new sight into Sal’s preference for CSCs and cancer cells. Low-dose salinomycin induces anti-leukemic responses in AML and MLL Gary D R Roulston, Charlotte L Burt, Laura M J Kettyle, Kyle B Matchett, Heather L Keenan, Nuala M Mulgrew, Joanne M Ramsey, Caoifa Dougan, John McKiernan, Ivan V Grishagin, Ken I Mills , Alexander Thompson 2019-02-14 · The aim of the present pre-clinical study was to investigate the impact of salinomycin on patient-derived colorectal cancer initiating cells. The results confirm that salinomycin exhibits increased anti-cancer stem cell activity compared to 5-FU and oxaliplatin in vitro .

the clinical trial.

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Methods: Primary tumor-initiating cells (TIC) isolated from human patients with colorectal liver metastases or from human primary colon carcinoma were exposed to salinomycin and compared to treatment with 5-FU and oxaliplatin. Salinomycin is as an antimicrobial and anticoccidial antibiotic.

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salinomycin, reduces the proportion of CSCs [cancer stem cells] by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. 2019-05-27 Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Therefore, salinomycin may be considered as a promising novel anti-cancer agent … 2017-01-30 Sacox® is intended to be incorporated into feedingstuffs directly and/or through premixtures. The Applicant proposed a concentration of salinomycin sodium in feedingstuffs of 50 mg/kg for chickens reared for laying or ranging from 60 to 70 mg/kg for chickens for fattening. In the present study, we used salinomycin (Sal) and 5-fluorouracil ( 5-FU) combination therapy on HCC cell lines Huh7, LM3 and SMMC-7721 and nude mice subcutaneously tumor model to study whether Sal could increase the sensitivity of hepatoma cells to the traditional chemotherapeutic agent such as 5-FU. Salinomycin (molecular formula, C 42 H 70 O 11) is a monocarboxylic polyether antibiotic isolated from Streptomyces albus strain (Strain No. 80614) . The usage of salinomycin in veterinary medicine can be traced back to 1980s as a broad spectrum antimicrobial agent with activity against gram-positive bacteria, fungi, and parasites [4–6].

To evaluate the effect of the contemporaneous addition of salinomycin and TRAIL in GBM cells, T98G and U251 cell lines were treated with a low concentration (i.e., 1.2 µM) of salinomycin, not suitable for inducing a significant reduction of viable cells and in the absence or in the presence of increasing concentrations of TRAIL. 2020-10-01 Salinomycin has already been tested in a pilot clinical trial and showed no severe acute or long-term side effects 11. Together, the data support the efficacy of salinomycin as an anti-leukemic at non-hemotoxic concentrations. Further investigation alone or in combination with other therapies is warranted for future clinical trial. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials.
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salinomycin in the feed additive, premixtures and feedingstuffs. For the quantification of salinomycin in chicken tissues the Applicant submitted a single laboratory validated and further verified method based on reverse phase HPLC coupled to a triple quadrupole mass spectrometer in electrospray ionisation mode using matrix Sacox® microGranulates, containing salinomycin sodium (SAL-Na), for chickens for fattening and chickens reared for laying have been recently re-evaluated by Panel on Additives and Products or Substances used in Animal Feed. Following an urgent request from the European Commission, the safety and efficacy of the product when fed to rabbits for fattening was assessed based on the available data Salinomycin sodium (SAL-Na) is active against certain Gram-positive bacteria, while Gram-negative species are resistant. SAL-Na at the proposed concentration is unlikely to increase shedding of Salmonella, Escherichia coli and Campylobacter and or induce resistance and cross-resistance to antimicrobials important in human and animal therapy. SAL-Na is safe for chickens for fattening at 70 mg Promising results from a few clinical pilot studies reveal that salinomycin is able to effectively eliminate cancer stem cells and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. Salinomycin News and Research RSS. Study identifies a host of agents with anti-SARS-CoV-2 potential.

Following an urgent request from the European Commission, the safety and efficacy of the product when fed to rabbits for fattening was assessed based on the available data Salinomycin sodium (SAL-Na) is active against certain Gram-positive bacteria, while Gram-negative species are resistant. SAL-Na at the proposed concentration is unlikely to increase shedding of Salmonella, Escherichia coli and Campylobacter and or induce resistance and cross-resistance to antimicrobials important in human and animal therapy. SAL-Na is safe for chickens for fattening at 70 mg Promising results from a few clinical pilot studies reveal that salinomycin is able to effectively eliminate cancer stem cells and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. Salinomycin News and Research RSS. Study identifies a host of agents with anti-SARS-CoV-2 potential. A team of researchers at the Genomics Research Center, Academia Sinica, 2020-11-30 · ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. Explore 375,253 research studies in all 50 states and in 220 countries.

Salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. It has also been demonstrated as a positive ionotropic and chronotropic agent that increased cardiac output, left ventricular systolic pressure, heart rate, mean arterial pressure, coronary artery vasodilatation and blood flow, and plasma Clinical Trial Klinisk prövning [Publikationstyp] Svensk definition.
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2020-10-01 Salinomycin has already been tested in a pilot clinical trial and showed no severe acute or long-term side effects 11. Together, the data support the efficacy of salinomycin as an anti-leukemic at non-hemotoxic concentrations. Further investigation alone or in combination with other therapies is warranted for future clinical trial. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. For the quantification of salinomycin sodium in premixtures and feedingstuffs the Applicant submitted the ring-trial validated method (EN ISO 14183) based on High Performance Liquid Chromatography with post-column derivatisation coupled to spectrophotometric detection (HPLC-UV-Vis). Emerging Mechanism of Action: Ferroptosis – Strengthens Company’s Oncology Pipeline.

Institutet för molekylärmedicin i Finland – Publikationer

PLoS One.2012;7(12):e50638. RESEARCH ARTICLE Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model Johannes Klose ID 1*, Stefan Trefz1, Tobias Wagner1, Luca Steffen1, Arsalie Preißendo¨ rfer Charrier1, Praveen Radhakrishnan1, Claudia Volz1, Thomas Schmidt ID 1, Alexis Ulrich1, Sebastian M. Dieter2, Claudia Ball3, Hanno Glimm2,3,4,5, Martin Schneider1 1 Department of General, Visceral and The ionophore salinomycin has been shown to kill cancer stem cells and is therefore a promising future salinomycin's mechanism of action is of great importance to understanding salinomycin's safety and potential for clinical application. 4. Salinomycin's effect on CSC National Cancer Institute of Canada Clinical Trials Group: Salinomycin is a polyether antibiotic with properties of an ionophore, which is commonly used as cocciodiostatic drug and has been shown to be highly effective in the elimination of cancer stem Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem … 2019-04-25 Important Must be Thoroughly Mixed in Feeds Before Use. Not approved for Use With Pellet Binders..

We summarize the autophagy-related researches, providing a new sight into Sal’s preference for CSCs and cancer cells. Low-dose salinomycin induces anti-leukemic responses in AML and MLL Gary D R Roulston, Charlotte L Burt, Laura M J Kettyle, Kyle B Matchett, Heather L Keenan, Nuala M Mulgrew, Joanne M Ramsey, Caoifa Dougan, John McKiernan, Ivan V Grishagin, Ken I Mills , Alexander Thompson 2019-02-14 · The aim of the present pre-clinical study was to investigate the impact of salinomycin on patient-derived colorectal cancer initiating cells. The results confirm that salinomycin exhibits increased anti-cancer stem cell activity compared to 5-FU and oxaliplatin in vitro . I am not aware of any studies in humans. So I think that you will struggle to find any people who have taken Salinomycin as a cancer treatment. In fact I would urge your friend to be cautious about using Salinomycin. This is because there is some evidence to suggest that it might be very toxic to humans and cause muscle weakness and heart problems.